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| Pharma and Chemical Intermediates |
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1,2-Hexanediol |
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Useful
intermediate for Polymer Synthesis, Applications in High Speed Ink Catridges |
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| Fine Chemicals |
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An efficient antioxidant, Alpha-Lipoic Acid at high dose levels has been shown to increase glucose uptake, indicating potential utility in the management of blood glucose levels. In diabetics, proteins tend to bind with glucose, precipitating oxidative damage. Alpha-Lipoic Acid supplementation reduces glycation of proteins, thereby offering protection. Alpha-Lipoic Acid also protects against cholesterol oxidation and the consequent atherosclerosis in diabetics as well as in others at risk of cardiovascular diseases1.
1. Packer, Lester, Ph.D., et al. (1995). Free Radical Biology and Medicine 19(2):227-250.
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Alpha-Lipoic Acid : An Efficient Antioxidant
by Muhammed Majeed, Ph.D. and Lakshmi Prakash, Ph.D. |
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Chrysin (5, 7-dihydroxyflavone) belongs to a biologically active class known as bioflavonoids. Chrysin has been isolated from Passiflora plants, such as P. coerulea (used as a sedative in folklore medicine)1 and P. incarnate (maracuja "passion flower" which is well known in traditional medicine for its diverse biological effects). The effects of Chrysin include anti-inflammatory action, antiviral (including anti-HIV) action, vasodilatory effects and anxiety-reducing action. Chrysin has also been shown to have a potential role in drug metabolism and the chemoprevention of carcinogenesis2. Laboratory studies, on in vitro and animal models, revealed that Chrysin inhibited the secretion of lysosomal enzymes and arachidonic acid, as well as the degranulation of mast cells, thereby reducing inflammation3.
1. Medina, JH et al. (1998) Planta Med. (Dec).
2. Eaton, E.A. et al. (1996) Drug Metab Dispos, 24 (2): 232-7.
3. Tordera, M. et al. (1994) Z Nuturforsch ICI, 49 (3-4): 235-240.
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Diosgenin is the primary furostanol saponin found in several plants including Dioscorea species (yams), fenugreek and Costus speciosus. The compound has been shown to be useful in the maintainence of healthy blood cholesterol levels1. Diosgenin is the starting material for the synthesis of a number of hormonal products such as DHEA. The estrogenic effects of diosgenin have also been demonstrated2.
1. Sauvaire, Y. et al. (1991) Lipids. 26(3):191-197.
2. Aradhana. Rao AR. Kale RK. (1992) Indian Journal of Experimental Biology, 30(5):367-70.
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Glucosamine Hydrochloride
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Glucosamine hydrochloride contains about 80% glucosamine, a compound which is helpful in maintaining joint health in degenerative conditions such as arthritis. It is an effective means of providing glucosamine orally, as a building block for the regeneration of cartilage glycosaminoglycans, lost during the progression of osteoarthritis. It is often used in the management of osteoarthritis and rheumatoid arthritis. When given orally, it is selectively taken up by joint tissues to exert beneficial effects. Glucosamine is clinically proven to retard the progression of degenerative changes in the joints1.
1. Tapadinhas, M.J. et al. (1982) Report on multicenter open investigation in Portugal., 3(3):,15-168
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Indole-3-carbinol is found in cabbage, broccoli and brussels sprouts and has been shown in pre-clinical experiments to be a promising nutrient. This fact may justify well published clinical evidence that eating cruciferous vegetables may be helpful in the prevention of various forms of cancer in humans1. A considerable body of pre-clinical evidence has been accumulated on the efficacy of Indole-3-carbinol in the prevention and intervention of direct and indirect acting carcinogens in the development of breast tumors in rodents2.
1. Jellinick, P. et al. (1994) J. Steroid Biochem & Molecular Biology. 51 (3-4): 219-225.
2. Loub. W.D. et al. (1975) JNCI, 54: 985-988.
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Organic Intermediates |
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R)-(+)- a -Amino- g -butyrolactone hydrochloride |
Chiral synthon |
(S)-(-)- a -Amino- g -butyrolactone hydrochloride |
Chiral synthon
Precursor to quorum-sensing signal molecules
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( ± )- a -Amino- g -butyrolactone hydrochloride |
Useful synthetic intermediate |
2-Bromo-5-methoxybenzoic acid |
Useful intermediate |
N-(Chloromethyl)phthalimide |
Useful protecting group |
4,6-Dimethoxysalicylaldehyde
(4,6-dimethoxy-2-hydroxy-benzaldehyde) |
Useful starting material |
N-Phthaloyl-L-glutamic acid |
Chiral synthon |
N-Phthaloyl-L-glutamic anhydride |
Chiral synthon
Useful for  -glutamyl
peptides
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m-Chloro phenol |
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1,2 HexaneDiol |
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1,2 Octanediol |
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2- Allyl Phenol |
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2 hydroxy 4,6 Dimethoxy benzaldehyde |
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3 Chloro alanine Hydrochloride
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Beta Cyclo Citral |
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Phenoxy acetic acid |
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Ethoxy –m- phenylene diamine |
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Pyridostigmine bromide
(Antidote to chemical warfare agents) |
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Eflornithine
(African sleeping sickness) |
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Dutasteride
(benign prostatic hyperplasia ) |
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Testolactone
( Antineoplastic ) |
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Thalidomide
(Immunomodulator) |
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Allyl L-selenocysteine
( Selenium Supplement ) |
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The products offered by Sabinsa Corporation are certified Kosher. |
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